KansaiUniversity

Japanese

KU SMART PROJECT

“Human-friendly materials that reach the target lesion”Medical polymers that enable non-invasive and smart diagnosis and care

Development of diagnostic technology
for "human-friendly" pulmonary hypertension using ultrasonic echo UTSUNO, Hideo, Professor, Faculty of Engineering Science
Department of Thoracic and Cardiovascular Surgery, Osaka Medical College

Pulmonary hypertension is a condition in which increased blood pressure in the arteries that send blood to the lungs, places a greater burden on the right ventricle and leads to a decline in blood circulatory function throughout the body.
It occurs in approximately 0.3% of newborn babies (around one million a year), and an increasing number of adults are contracting the condition. In Japan,the government has designated the condition as an intractable disease.
As shown in Figure 1, there are two known causes of pulmonary hypertension: (1) an obstruction in one of the arteries of the lung, and (2) perforation in the interatrial septum or interventricular septum. The treatment will vary depending on the cause, thus making it essential to identify the cause at the time of diagnosis.
The present approach for pulmonary hypertension is as follows: after the patient is screened using an echocardiogram or similar device, the pulmonary arterial blood pressure is measured more precisely using an intracardiac catheter, and the oxygen saturation in arterial blood samples is measured to identify the cause.

Fig. 1 Pulmonary hypertension and its causes
Using non-invasive ultrasonic echo to diagnose pulmonary hypertension
and identify its cause instantaneously
Fig. 2 Waveforms of blood pressure and blood flow velocity (analytical value) Table 1 Relational expression between blood pressure and blood flow rate Fig. 3 Theoretical relationship between occlusion degree and phase Determination of clinical data using cardiac catheter Basic experiment using ultrasonic echo
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