Research Topics

① Isolation and characterization of novel enzymes from microorganisms
② Enzymological and microbial production of industrially useful compounds and D-amino acids
③ Analysis and function of D-amino acids in foods

Key Words

D-Amino Acid, Novel Enzyme, Stereospecific Synthesis, Biocatalyst, Screening of Novel Microorganisms, Fermentative Food, Thermostable Enzymes

Applications

Production of Food Additive, Functional Food, Medicine, Agricultural Chemicals, and Biopolymer; Food Process; Biomass; Biosensor

Research Topics

① Drug discovery of bioactive compounds
② Discovery of natural products
③ Construction of chemical library
④ Identification of molecular mechanism of bioactive compounds

Key Words

Medicinal Chemistry, Protein-Protein Interaction, Epigenetics, Chemical Library, Natural Products, Neurodegenerative disease, Anticancer Drug, Drug Delivery to Brain

Applications

Pharmaceuticals, Drug Discovery

Research Topics

① Explorative study of bioactive compounds
② Synthesis of functional molecules
③ Pharmaceutical engineering

Key Words

Drug Discovery, Natural Products, Molecular Target Drugs, Gene Delivery, Polyphenol, Histone Deacetylase Inhibitor

Applications

Pharmaceuticals, Cosmetics, Dietary Supplements

Research Topics

① Genomics-guided Discovery of Biosynthetic Genes for Novel Bioactive Molecules
② Biosynthetic Studies for Structurally Unique Microbial Bioactive Molecules
③ Development of a Genetic Platform for Efficient Production of Bioactive Molecules

Key Words

Genome-mining, Natural product, Biosynthesis,
Microbial genetics, Actinobacteria,
microbial production, fermentation

Applications

Pharmaceutical and Agricultural drugs,
Food preservatives, Cosmetics, Biopolymers, Chemicals

Research Topics

① Genetic Engineering of Fish

Key Words

Myogenesis, Development, Medaka, Genetic engineering

Applications

Genetic engineering of aquatic animals, Congenital disease analyses, Drug discovery

Research Topics

① Cell plate formation in higher plant cells
② The role of microtubule associated proteins in cell division and cell elongation

Key Words

Plant Cytokinesis, Phragmoplast, Cell Plate, Microtubules, Actin Filaments, Cytoskeleton

Applications

Breeding of Plants

Research Topics

① Molecular and neural mechanisms of the circadian rhythm

Key Words

Circadian rhythm, Suprachiasmatic nucleus, Clock gene

Applications

Health science, Pharmaceutical intervention, Bioreporter, Biosensor

Research Topics

① Analysis and development of bacterial metabolic activities for xenobiotics and its application for bioremediation of environmental pollution
② Ecological study of xenobiotics degrading bacteria in soil and marine environments

Key Words

Biodegradation, Bioconversion, Nitroaromatics, Marine Bacteria, Baeyer-Villiger monooxygenase

Applications

Bioremediation of Xenobiotics, Bioconversion of Xenobiotics-related Compunds to Useful Chemicals, Wastewater Treatment

Research Topics

① Aerobic fed-batch culture of lactic acid bacteria for high cell density cultivation
② Interaction of lactic acid bacteria with dietary fibers and intestinal mucin
③ Production of hyaluronic acid with high molecular size by a bacterium
④ Production of ethanol from waste paper by consolidated continuous solid state fermentation

Key Words

lactic acid bacteria, fed-batch culture, hyaluronic acid, bioethanol, dietary fiber

Applications

Efficient production of lactic acid bacteria, hyaluronic acid, bioethanol

Research Topics

① Bioremediation of chemical pollutants by environmental bacteria and their activities
② Investigation of biofilm formation and development of biofilm removal system
③ Disinfection of microorganisms
④ Bioenergy production and biomass utilization
⑤ Outbreak mechanism of stress resistant bacterial and their resistant mechanism

Key Words

Bioremediation, Chemical Pollutant, Cytochrome P450 Monooxygenase, Molecular Chaperone, Protein Stability, Biofilm, Surfactant, Reactive Oxygen Species, Disinfectant, Sterilization System, Stress Response, Genetics, Endogenous Plasmid, Biodiesel, bioenergy, biomass

Applications

Sewage Disposal System, Improvement of Polluted Soil, Development of Disinfectant, Food Processing, Pharmaceutical Manufacturing, Medicals, Enzymatic Industry

Research Topics

① Metabolic Engineering of Microorganisms
② Construction of Artificial Microbiota
③ Genome Editing of Microorganisms

Key Words

Metabolic Engineering, Artificial Microbiota, Genome Editing, Cell Penetrating Peptide, Peptide Nucleic Acid, Bacteriophage

Applications

Bio-refinery, Production of Useful Compounds, Modification of Microbial Functions, Analysis of Microbial Interactions

Research Topics

① Development of novel antimicrobial technology

Key Words

Antimicrobial compound, Antimicrobial action, Antimicrobial resistance, Biofilm, Biorefinery, Environmental impact assessment, Bioremediation

Applications

Microbial control, Antimicrobial technology

Research Topics

① Analysis of functions of membrane vesicles produced from intestinal bacteria
② Analysis of immune regulatory functions of intestinal bacteria
③ Understanding the interactions between intestinal bacteria and intestinal tract or dietary fiber
④ Application of probiotics microbial components as adjuvants

Key Words

Intestinal bacteria, Probiotics, membrame vesicle, Gut immunity

Applications

Functional food, Vaccine adjuvant, Cosmetics

Research Topics

① We study on the absorption, metabolism, nutrigenomics, and chemistry of marine functional compounds such as n-3 polyunsaturated fatty acid or marine organic compounds.
② Our research project also includes attempts to improve protein functionality, food process characteristics and biofunctions, using molecular modification.

Key Words

Fish Oil, n-3 Polyunsaturated Fatty Acid, Fish Protein, Fish Peptide, Marine Products, Protamine

Applications

Functional Foods, Utilization of Marine Bio-resources, Materials of Pharmaceutical Compounds

Research Topics

① Nutritional approach to minerals and trace elements in foods
② Environmental assessment of urban and rural area using community of butterflies

Key Words

Trace Elements, Nutrition, Food, Iron, Copper, Selenium, Zinc, Iodine, Chromium, Molybdenum, Dietary Reference Intake, Butterfly, Urban Environment

Applications

Nutritional Enrichment, Nutritional Supplements, Analysis of Trace Elements, Nutritional Assessment, Environmental Assessment

Research Topics

① Influence of Superchilling (Hyo-On) Treatment on Food Components
② Health Promoting Effect of Novel Component Derive from Seafood

Key Words

Superchilling (Hyo-On), Food Preservation, Aging, Seafood, Fish Protein, Marine Phospholipid

Applications

Food Preservation Technology, Novel Aging Technology, Functional Food and Component